Nuvalent, Inc. is a biotechnology company focused on developing targeted therapies for patients with cancer. With a strong foundation in chemistry and structure-based drug discovery, Nuvalent designs innovative small molecules to effectively inhibit kinase targets, overcoming challenges of resistance and selectivity. The company collaborates with physician-scientists to address patient needs and limitations of existing therapies, ensuring their solutions are built for patients and driven by a deep sense of purpose. Nuvalent is committed to using their expertise to deliver precisely targeted cancer treatments.
February 20
Nuvalent, Inc. is a biotechnology company focused on developing targeted therapies for patients with cancer. With a strong foundation in chemistry and structure-based drug discovery, Nuvalent designs innovative small molecules to effectively inhibit kinase targets, overcoming challenges of resistance and selectivity. The company collaborates with physician-scientists to address patient needs and limitations of existing therapies, ensuring their solutions are built for patients and driven by a deep sense of purpose. Nuvalent is committed to using their expertise to deliver precisely targeted cancer treatments.
β’ Lead the generation, analysis, and documentation of clinical biomarker data, including next generation sequencing with tissue and plasma samples, gene expression profiling, and histopathology assays β’ Conduct in-depth analysis and interpretation of biomarker data including in the context of other types of clinical data, and present findings in internal meetings β’ Overseeing activities at contracting clinical translational biomarker labs β’ Oversee nonclinical translational biology studies, including monotherapy and/or combination studies in disease relevant models in CROs and collaborating labs β’ Work closely with clinical operations and sample management to oversee activities at central labs and contribute to implement/improve sample strategy β’ Effectively collaborate across internal functions including biology, clinical operations, clinical pharmacology, clinical science, data management, sample management, statistics, and quality, to ensure successful execution in the clinic β’ Represent Translational Medicine within a cross functional multi-disciplinary clinical study team, provide biomarker/scientific support, to meet project milestones for translational medicine responsibilities β’ Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions; lead or contribute to the development of abstracts, external presentations, and publications
β’ A Ph.D. in cancer biology, cell/molecular biology, genomic biology or equivalent with 3+ years of industry experience after PhD, or an M.S. with 10+ years of industry experience. β’ Proficient in bioinformatic skills including using R and/or python in data analysis and plotting β’ Deep knowledge of oncology kinase pathways, tumor biology and drug resistance β’ Knowledge of clinically relevant biomarker assay types (such as NGS, RNAseq, IHC/mIF, and FISH) β’ Experience in providing biomarker support for registrational trial(s) and/or companion diagnostics is a plus
Apply NowJanuary 23
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