Staff Software Engineer - Bioinformatics

March 14

Apply Now

Receive Emails with Similar Jobs

GeneDx

WebsiteLinkedInAll Job Openings

At GeneDx, we believe that everyone deserves personalized, targeted medical care—and that it all begins with a genetic diagnosis. Fueled by one of the world’s largest rare disease data sets, our industry-leading exome and genome tests translate complex genomic data into clinical answers that unlock personalized health plans, accelerate drug discovery, and improve health system efficiencies. It all starts with a single test.

genetic testing • rare genetic disorders • molecular diagnostics • whole genome sequencing • next generation sequencing

1001 - 5000 employees

📋 Description

• GeneDx, the world’s leading genomics diagnostics company, is seeking a Senior Software Engineer/Bioinformatician for our Bioinformatics Platform team. • As a Senior Software Engineer, you will work with other engineers and bioinformaticians in our team to deliver faster, cheaper, more reliable, more scalable, and more accurate bioinformatics software into our production diagnostics platform. • You will lead technical design and implementation efforts to improve our bioinformatics workflow and bioinformatics algorithms; executing using the best practices and principles of modern software engineering. • You will lead analytical validation efforts in support of new pipeline development and existing pipeline improvements. • Your breadth of engineering knowledge will allow you to make and review plans for complex projects that may include other engineering specialties (e.g. devops).

🎯 Requirements

• Proficiency in Python; comfortable with working in other similar languages • Experience building/consuming API calls/responses and ETL functions. • Experience with AWS services, Docker, Kubernetes, Helm, CI/CD, automated testing, and data logging suites/toolsets. • Good understanding of general software engineering patterns, best practices, and methods. • 8+ years professional experience (industry setting) designing and supporting robust applications using modern object-oriented frameworks. • Able to define and execute work across platforms over multiple quarters, as a technical project lead and contributor. • Have developed novel bioinformatics algorithms and products. • Track record of influential publications or leadership of scientific collaborations. • Successful history of delivering scalable production software. • Excellent communication skills; ability to work collaboratively with other development teams. • Knowledge of bioinformatics pipeline scalability, observability, and cost efficiency. • Be able to lead, coordinate, and execute validation efforts for new products. • Deep understanding of technical implementation of complex variant calling - structural variants beyond copy number. • Ability to improve existing variant calling algorithms. • Technical knowledge of NGS and non-NGS laboratory assays. • Prior experience working in a CAP/CLIA regulated setting. • Prior experience preparing for a CAP/CLIA inspection. • Understanding of assay panel design considerations. • Able to coordinate and execute efforts for modifications to existing bioinformatics products. • Experience troubleshooting wet-lab and dry-lab issues. • Strong understanding of bayesian statistics and ML in relation to common bioinformatics applications. • Familiarity with samtools, gatk, picard, vcftools, bedtools. • Familiarity with bioinformatics workflow management tools and concepts. • PhD strongly preferred.

🏖️ Benefits

• Paid Time Off (PTO) • Health, Dental, Vision and Life insurance • 401k Retirement Savings Plan • Employee Discounts • Voluntary benefits