Scientist - Molecular Design

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Description

• Terray Therapeutics is a venture-backed biotechnology company. • The candidate will design combinatorial libraries for our platform and contribute to hit-to-lead and lead optimization efforts across multiple drug discovery programs. • Work closely with the chemistry and biology functions at Terray, as well as the machine learning, data science, and software teams within CDS. • Design focus libraries and productionize library design methods that use our proprietary ML models and other computational tools. • Develop metrics to assess and improve library designs. • Extract insights from our ultra-large proprietary screening datasets in collaboration with data scientists and cheminformaticians. • Contribute to the design of small molecules with in-house, high-throughput computational tools using both structure-based and ligand-based models. • Communicate molecular design strategy and outcomes to teams across the company.

Requirements

• BS/MS/Ph.D in computational, organic, or medicinal chemistry, or a related field • Experience designing small-molecule libraries for virtual screens, DEL screens, and/or HTS • Experience triaging large data sets from virtual screens, DEL screens, and/or HTS • Proficient in Python and the PyData stack (numpy, pandas, scipy, scikit-learn, etc.) • Familiar with ligand-based and structure-based methods to designing small molecules for drug discovery projects • Experience with RDKit, and familiarity with molecular simulation suites (Schrodinger, MOE, etc.) and docking programs (AutoDock Vina, rDock, etc.)

Benefits

• 3% retirement safe harbor contribution • fully paid medical, dental, vision, life and disability benefits