Medical Director

March 22

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Karyopharm Therapeutics Inc.

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Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company dedicated to pioneering novel cancer therapies. Driven by a belief in the extraordinary strength and courage of cancer patients, the company focuses on scientific innovation to develop potentially life-changing treatments for cancers with high unmet medical needs. Karyopharm is at the forefront of Selective Inhibitor of Nuclear Export (SINE) technology, addressing fundamental mechanisms of oncogenesis through ongoing clinical trials for various types of tumors, including hematologic malignancies and solid tumors.

oncology • pharmaceutical • biotech • multiplemyeloma • lymphoma

201 - 500 employees

Founded 2008

💊 Pharmaceuticals

⚕️ Healthcare Insurance

🧬 Biotechnology

📋 Description

• The Medical Director will serve as the primary medical lead for Karyopharm study team within assigned clinical trials. • Serves as the primary Medical Monitor responsible for monitoring the safety of enrolled subjects on assigned trials. • Participate in the development of Study Protocols, Investigator's Brochures, Clinical Development Plans and other key study documents. • Serve on cross-functional teams for assigned trials, working with other team members to achieve efficient, high-quality study execution. • Participate in the preparation of regulatory documents in support of regulatory submissions. • Provide scientific and clinical input to study-related documents and analysis plans. • Act as liaison between Clinical Development and other internal groups at Karyopharm for assigned studies. • Participate in development of and execute life-cycle management plan, lead data generation activities. • Support Medical Affairs: Working with field medical, Scientific Communication and Publication, Medical Information and Communication teams. • Help identify and effectively interact with thought leaders to engage in scientific and medical exchange. • Maintain a high level of clinical and scientific expertise in the disease area(s). • Author manuscripts and collaborate with cross-functional colleagues and thought leaders. • Maintain ethical standards of the highest level and comply with all relevant standards. • May participate in or lead clinical development contributions to due diligence or other business development activity. • Present at scientific, medical and regulatory meetings globally. • Develop and maintain relationships with academic investigators, pharmaceutical partners/sponsors, KOL’s, and patient advocacy groups.

🎯 Requirements

• MD, DO or equivalent ex-US medical degree. • 4+ years clinical trial experience in an academic or industrial setting. • Experience in analysis of research data and publications; working knowledge of biostatistics and pharmacokinetics. • Working knowledge of GCP, scientific and clinical research methods and clinical study design, regulatory requirements for clinical studies. • Completion of an Internship and/or Residency as a physician in oncology, hematology, internal medicine, or relevant medical specialty area. • Cancer research experience. • Pharmaceutical/Biotech industry experience or Academic experience, including time managing clinical trials and/or clinical development program(s). • Excellent oral and written communication skills. • Ability to work collaboratively in a fast-paced, team-based matrix environment and to function independently as appropriate.

🏖️ Benefits

• Competitive salary, bonus, and generous equity offerings (RSU’s at time of offer and annual awards) – we are partners in prosperity! • Peace of mind through best in class medical (deducible paid by KPTI), dental, vision, disability, and life insurance, parental leave, a matching 401k program (immediate vesting), ESPP and tuition reimbursement. • Wellness Program with a monthly stipend. • Generous PTO and Holidays – we encourage you to recharge and spend time with family and friends. • Ample opportunities to learn and take on new responsibilities in a fast-paced, and patient focused company. (tuition reimbursement, management development & mentoring programs, and a variety of reward and recognition programs) • Cell phone allowance