Senior Scientist, Molecular Design

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Description

• Design small molecules with in-house, high-throughput computational tools using both structural models and ligand-based data from proprietary screening platform • Develop strategies to assess and progress hits across multiple programs for internal pipeline and partnered projects • Design focus libraries to drive small molecule programs in hit-to-lead and lead optimization • Develop and evaluate models and generative tools to design compounds with desired properties in collaboration with the machine learning team • Communicate molecular design strategy and outcomes to teams across the company

Requirements

• BS/MS/Ph.D in computational, organic, or medicinal chemistry, or a related field • Experience applying ligand-based and structure-based methods to designing small molecules for multiple drug discovery projects • Experience working with medicinal chemists to optimize ADME and safety issues • Experience triaging large data sets from virtual screens, DEL screens, and/or HTS • Experience with RDKit, molecular simulation suites (Schrodinger, MOE, etc.), and docking programs (AutoDock Vina, rDock, etc.) • Proficient in Python and the PyData stack (numpy, pandas, scipy, scikit-learn, etc.)

Benefits

• 3% retirement safe harbor contribution • full y - paid medical, dental, vision, life and disability benefits